Abstracts and Comments follow the links for each publication
Publications
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X-ray structure of the T. aquaticus FtsY:GDP complex suggests functional roles for the C-terminal helix of the SRP GTPases
Joseph Gawronski-Salerno, Pamela J. Focia, John S. Coon V.
& Douglas M. Freymann
Proteins (2007) 66 984-995 -
Structure of the GMPPNP-stabilized NG domain complex of the SRP GTPases Ffh and FtsY
Joseph Gawronski-Salerno & Douglas M. Freymann
J. Struct. Biol. (2007) 158 122-128 -
Analysis of protein hydration in ultra-high resolution structures of the SRP GTPase Ffh
Ursula D. Ramirez & Douglas M. Freymann
Acta Cryst. (2006) D62 1520-1534 -
Structure of a GDPAlF4 complex of the SRP GTPases Ffh and FtsY, and identification of a peripheral nucleotide interaction site
Pamela J. Focia, Joseph Gawronski-Salerno, John S. Coon V,
& Douglas M. Freymann
J. Mol. Biol. (2006) 360 631-643
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Novel Protein and Mg2+ Configurations in the Mg2+GDP Complex of the SRP GTPase Ffh
Focia, P.J., Alam, H., Lu, T., Ramirez, U.D., & Freymann, D.M
Proteins (2004) 54 222-230 -
Purification of RanGDP, RanGTP, and RanGMPPNP by ion exchange chromatography (2004) Bibak, N., Paul, R.M.J., Freymann, D.M. & Yaseen, N.R (2004) Analytical Biochemstry 333 57-6
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Heterodimeric GTPase core of the SRP targeting complex
Focia, P.J., Shepotinovskaya, I.V., Seidler, J.A. & Freymann, D.M.
Science (2004) 303 373-377 -
Crystallization of the GMPPCP complex of the NG domains ofT. aquaticus Ffh and FtsY (2003) Shepotinovskaya, I.V., Focia, P.J., & Freymann, D.M. Acta Cryst. D59 1834-1837.
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Structural basis for mobility in the 1.1Å crystal structure of the NG domain of T. aquaticus Ffh (2002) Ramirez, U.D., Minasov, G., Focia, P.J., Stroud, R., Walter, P., Kuhn, P., & Freymann, D.M. J. Mol. Biol. 320 783-799
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Conformational change of the N-domain accompanies formation of the complex between the GTPase domains of Thermus aquaticus Ffh and FtsY (2002) Shepotinovskaya, I. & Freymann, D.M. Bioch. Biophys. Acta. 1597 92-99.
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Conserved tryptophan in the core domain of transglutaminase is essential for catalytic activity (2002) Murthy, S.N.P., Iismaa, S., Begg, G., Freymann, D.M., Graham, R.M., & Lorand, L. Proc. Natl. Acad. Sci. 99 2738-2742.
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The Signal Recognition Particle (2001) Keenan, RJ, Freymann DM, Stroud RM, & Walter P Annu Rev Biochem 70 755-775.
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The conformation of bound GMPPNP suggests a mechanism for gating the active site of the SRP GTPase (2001) Padmanabhan, S. & Freymann, D.M. Structure 9 859-867.
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Role of 4.5S RNA in Assembly of the Bacterial Signal Recognition Particle with its Receptor (2000) Peluso, P., Herschlag, D., Nock, S., Freymann, D.M., Johnson, A.E. & Walter, P. Science 288 1640-1643
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The Crystal structure of Thymidylate Synthase from Pneumocystis carinii Reveals a Fungal Insert Important for Drug Design (2000) Anderson, A., Perry, K., Freymann, D.M. & Stroud, R.M. J. Mol. Biol. 297 645-657
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Efficient identification of inhibitors targeting the closed active site conformation of the HPRT from Trypanosoma cruzi (2000) Freymann, D.M., Wenck, M.A., Engel, J.C., Feng, J., Focia, P.J., Eakin, A.E., & Craig, S.P.III Chemistry & Biology 7 957-968.
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Structure of the phylogenetically most conserved domain of SRP RNA (1999) Schmitz, U., Behrens S., Freymann, D.M., Keenan, R.J., Lukavsky, P., Walter, P. & James, T.L. RNA 5 1419-1429
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Functional changes in the structure of the SRP GTPase on binding GDP and Mg2+GDP (1999) Freymann, D.M., Keenan, R.J., Stroud, R.M., & Walter, P. Nature Structural Biology 6 793-801
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Crystal Structure of the Signal Sequence Binding Subunit of the Signal Recognition Particle (1998) Keenan, R. J., Freymann, D. M., Walter, P. & Stroud, R.M. Cell 94 181-191.
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Ion-channel-forming colicins (1998) Stroud, R.M., Reiling, K., Wiener, M. & Freymann, D. Curr. Opin. Struct. Biol. 8 525-533.
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Structure of the conserved GTPase domain of the signal recognition particle (1997) Freymann, D.M., Keenan, R.J., Stroud, R.M. & Walter, P. Nature 385 361-364.
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NMR studies of the most conserved RNA domain of the mammalian signal recognition particle (SRP) (1996) Schmitz, U., Freymann, D.M., James, T.L., Keenan, R.J., Vinayak, R., & Walter, P. RNA 2 1213-27
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Functional substitution of the signal recognition particle 54-kDa subunit by its Escherichia coli homolog. (1993) Bernstein, H.D., Zopf, D., Freymann, D.M., & Walter, P. Proc Natl Acad Sci 90 p 5229-33
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The 2.9Å Resolution Structure of the N-terminal domain of a variant surface glycoprotein fromTrypanosoma brucei (1990) Freymann, D., Down, J., Carrington, M., Roditi, I., Turner, M. & Wiley, D.C J. Mol. Biol. 216 141-160.
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Two variant surface glycoproteins of Trypanosoma brucei of different sequence classes have similar 6 A resolution X-ray structures. (1987) Metcalf, P., Blum, M., Freymann, D., Turner, M., & Wiley, D.C. Nature v325 p84
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Protein, DNA, and virus crystallography with a focused imaging proportional counter. (1986) Durbin, RM, Burns, R, Moulai, J, Metcalf, P, Freymann, D, Blum, M, Anderson, JE, Harrison, SC, & Wiley, DC Science v232 p1127
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6Å Resolution X-ray Structure of a variable surface glycoprotein fromTrypanosoma brucei (1984) Freymann, D.M., Metcalf, P., Turner, M., & Wiley, D.C. Nature 311 167-169.